Three days after you stop smoking, your body naturally reduces nicotine levels. Knowing this is essential because this is the point when many people experience their first symptoms of nicotine withdrawal. The most common ones include headaches, irritability, and mood swings as your body learns to live without nicotine.

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"The best way to quit smoking is with a combination of medication and counseling," says Maher Karam-Hage, M.D., medical director of the Tobacco Treatment Program at MD Anderson. "They both help. But you double your chances by using both compared with one of them."